Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery and the methodologies for carrying it out are brought together in a comprehensive work, Non-Clinical Vascular Infusion Technology, Two Volume Set: Science and Techniques. Volume 1 covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. 203 p. (vol. 1).
- Owen P. Green, MS in Pharmacological Biochemistry, PhD. Toxicologist in the preclinical toxicology industry within leading global CROs or as an independent consultant in Toxicology to pharmaceutical and chemical sectors; Founder and current Chairman of the Infusion Technology Organisation, Neuendorf (Switzerland), International group set up to share commercial and academic experiences with the technology in order to improve the techniques and scientific understanding for the benefit of the animal models involved and to improve the scientific quality of the data generated.
- Guy Healing, BSc in Biochemistry, PhD, Fellow of the British Toxicology Society, Experienced regulatory toxicologist who has worked in pre-clinical pharmaceutical R&D for nearly 20 years, and prior to that in agrochemical R&D and for a global CRO; Investigating the role of iron and oxygen-derived free radicals in the pathogenesis of renal ischaemic damage while working for the Medical Research Council (UK).
- Publisher: CRC Press
- Publication date (print): 2014 (copyright)
- ISBN (print): 978-1-4398-7440-0 [2 volume-set]
- ISBN (ebook PDF vol. 1): 978-1-4398-7450-9