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Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included. 488 p.

 

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Authors expertises affiliations

  • Rajesh Uthamanthil, Editor. DVM, PhD, Director of the Patient-derived Xenograft (PDX) Core; Director of Comparative Medicine Program, Fred Hutchinson Cancer Research Center, Seattle, WA (USA).
  • Peggy Tinkey, Editor. DVM, PhD, Dipl.ACLAM, Professor of Comparative Medicine; Chairman of the Department of Veterinary Medicine and Surgery. University of Texas M.D. Anderson Cancer Center, Houston, TX (USA).
  • Elisa de Stanchina, Associate Editor. Director ot the Memorial Sloan Kettering Cancer Center Antitumor Assessment Core Facility, NY (USA).

     
  • Publisher: Academic Press (imprint of Elsevier)
  • Publication date (print): 2016-10
  • ISBN (print): 978-0-12-804010-2

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